Goal: Archive high quality variation and phenotype information
Aggregates information about sequence variation and its relationship to human health
Submitter-driven
ClinVar will integrate data for same genotype/phenotype combination and highlight conflicts
ClinVar did calculate values for clinical significance and are currently reviewing some cases
Anticipated use
Search DNA or protein location for what is known about sequence variations at the location
Review evidence about phenotype associated with allele
Access
Public access
How to Retrieve Data
Enter search terms into search box on ClinVar Homepage. This preliminary release of ClinVar provides basic query and retrieval functions. Not all the content within ClinVar is being displayed from the website, although it is available via FTP (see below).
Browse via: variant, gene, location, submitter, and other categories
Platform for Human Leukocyte Antigen (HLA) community to submit, edit, view and exchange DNA and clinical data related to the human major histocompatibility complex (MHC)
Integrated with International Histocompatibility Working Group (IHWG), whose projects include:
Hematopoietic cell transplantation: HLA genotype and clinical outcome data
Type I diabetes
Rheumatoid arthritis: HLA genotype, microsatellite, clinical and demographic data
Access
Public access
Can access as guest or member
Guest
Cannot submit data
Cannot edit existing data
Data not saved from session to session or frame to frame
Can download data from a session
dbMHC Member
On dbMHC homepage, select "Create an Account" under "Accounts"
Provide institutional information
Specify account administrator
How to Retrieve Data
Several resources available for accessing data:
Alignment viewer for HLA and related genes
MHC microsatellite database (dbMHCms)
Sequencing interpretation site for Sequence Based Typing (SBT)