Do glucocorticoids, alone or combined with bronchodilators, show or provide benefit to children with acute viral bronchiolitis? Does the use of glucocorticoids have any effect on admission or hospital stay length?
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P (Patient, population) = child (aged 0-12) witn bronchiolitis
I (Intervention) = glucocorticoids or steroids
C (Comparison) = none/not using glucocorticoids or steroids
O (Outcome) = shorter admission or no admission at all
T (Type of Question) = therapy
T (Type of Study) = therapy hierarchy starting with systematic review of randomized trials
Search as entered in PubMed: (Glucocorticoids OR steroids) AND bronchiolitis AND (child or pediatric)
PubMed Search Details: (("glucocorticoids"[Pharmacological Action] OR "glucocorticoids"[MeSH Terms] OR "glucocorticoids"[All Fields]) OR ("steroids"[MeSH Terms] OR "steroids"[All Fields])) AND ("bronchiolitis"[MeSH Terms] OR "bronchiolitis"[All Fields]) AND (("child"[MeSH Terms] OR "child"[All Fields]) OR ("pediatrics"[MeSH Terms] OR "pediatrics"[All Fields] OR "pediatric"[All Fields]))
Type of Article: Use either the Article Type filter or a Clinical Query search to see if there are Meta-Analysis or Systematic Reviews.
1: Ng C, Foran M, Koyfman A. Do glucocorticoids provide benefit to children with bronchiolitis? Ann Emerg Med. 2014 Oct;64(4):389-91. doi: 10.1016/j.annemergmed.2014.01.026. Epub 2014 Feb 28. Review. PubMed PMID:24582604..
2: van Dellen QM, Kreier F, de Kruiff CC, Boluyt N, Fijnvandraat K. Question 2. Does combined oral dexamethasone and epinephrine inhalation help infants with bronchiolitis to recover faster? Arch Dis Child. 2011 Jun;96(6):606-8. doi: 10.1136/archdischild-2011-300067. Review. PubMed PMID: 21562339.
3: Hartling L, Fernandes RM, Bialy L, Milne A, Johnson D, Plint A, Klassen TP, Vandermeer B. Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis. BMJ. 2011 Apr 6;342:d1714. doi: 10.1136/bmj.d1714. Review. PubMed PMID: 21471175; PubMed Central PMCID: PMC3071611.