Also, if you are planning to use Zotero with a word processor such as Microsoft Word, you can download the Zotero word processor plugins by following the instructions on their word processor plugin installation page. Since Zotero is open-source, there are also community developed plugins listed on their plugin page. Most of these plugins aren't of much use to the general user, but browse the options to see if something may be useful or fun for you. For mobile support, check their mobile page which has options available for both iOS and Android phones.
After installation, you will need to set up your preferences to allow for syncing and cloud storage of your references. You can do this by first loading your Zotero section of your browser by clicking on the Zotero icon that ought to be in the bottom left corner, then clicking on the gear icon in your Zotero section of your browser and select Preferences.
Next click on the Sync tab of the Preferences window. Enter in your username and password to your account and select the Sync automatically option. If you would like to be able to access the attached files remotely, then select the Sync attachment files in My Library using Zotero. As of May 2017, Zotero gives all users 300MB of storage for free. Additional storage can be purchased on their website, however other citation management systems such as EndNote offer more functionality if you are going to pay for the service. Most PDFs range in size from 100KB to 1MB. So Zotero's free storage can hold between 300 and 1,200 PDFs, depending on the size of the PDFs.
Additionally, this will allow you to access your library when you're away from your personal computer through the My Library section of Zotero.org. You can manually add references using their website and it will sync with your library on your personal computer. The web interface for Zotero is not as powerful as EndNote, the other citation management software that we at the Health Sciences Library support, but it will give you basic functionality to add a reference if you have the citation information handy. If you're in a lecture where a paper by John Smith about something to do with Asymmetry published in Nature in 2003 is mentioned, you can add a reference on the Zotero website and tag the article with "follow up" or "to-do" to remind you to dig up the actual paper when you have some free time.
The Main Zotero Pane
Once you've installed Zotero, you can access the web extension for Zotero by clicking the Zotero button to the bottom left of Firefox. To access the stand-alone client on your computer, open it from the programs menu; if you have not yet added the Zotero connector for your browser, you can do so from the stand-alone installation webpage.
The above image displays the layout of the Zotero pane. From left to the right the buttons are for: